A psychic doctor, John Clancy (Sir Anthony Hopkins), works with an F.B.I. Special Agent (Jeffrey Dean Morgan) in search of serial killer Charles Ambrose (Colin Farrell). After having lived in isolation for two years, since the death of his daughter, Clancy is asked by his friend Joe, an F.B.I. Special Agent to help him solve several murders committed by a serial killer. The problem is that Ambrose is also psychic, and far ahead of Clancy.

When Lou finds himself in trouble, Nick and Jacob fire up the hot tub time machine in an attempt to get back to the past. But they inadvertently land in the future with Adam Jr. Now they have to alter the future in order to save the past - which is really the present.

It's been 20 years and Harry Dunn has found something out - he has a daughter! Lloyd Christmas, his equally dim witted friend, takes one look at a picture of her, develops a crush, and insists the two track her down. What ensues when Harry finally agrees is a bizarre encounter with an old lady and more hilarity because of their sheer stupidity.